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. 2022 Apr 14;13:872988. doi: 10.3389/fphar.2022.872988

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Copyright © 2022 Zhang, Wan, Zhou, Zhang, Zhao, Ma, Dong, Yan, Zhao and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Significant shift in physiologic and biochemical parameters and kidney pathology in DKD rats, and the effects of TSF treatment on renal damage. (A) Body weight of rats in the sham and DKD groups. *p < 0.05, **p < 0.01, versus sham rats. (B) Urinary parameters of sham and DKD rats. (C) Biochemical parameters in rat serum in the sham and DKD groups. (D) H&E, Masson trichrome, and PAS staining. (E–G) Semi-quantification of mesangial matrix, fibrosis area, and inflammatory scores based on PAS, Masson trichrome, and H&E staining, respectively. *p < 0.05, **p < 0.01.