TABLE 4.

Main biological side effects

Side effect	Result for the following group (no. of patients):		P valuea
	Ritonavir (25)	Ritonavir + saquinavir (22)
Triglyceride increaseb, no. (%)	23 (92)	20 (91)	1.00
Mean ± SD at baseline (mmol/liter)	2.1 ± 1.6	1.7 ± 1.4	0.32
Range at baseline (mmol/liter)	0.6–8.1	0.5–5.8
Mean ± SD at wk 24 (mmol/liter)	4.2 ± 1.7	3.9 ± 3.2	0.88
Range at wk 24 (mmol/liter)	0.9–7.4	0.8–13.1
Cholesterol increaseb, no. (%)	7 (28)	6 (27)	0.96
Mean ± SD at baseline (mmol/liter)	4.7 ± 0.9	4.3 ± 0.9	0.09
Range at baseline (mmol/liter)	3.5–6.7	2.5–6.6
Mean ± SD at wk 24 (mmol/liter)	6.4 ± 1.7	5.7 ± 1.3	0.39
Range at wk 24 (mmol/liter)	4.4–10.4	4.2–8.8
ALAT increasec, no. (%)
Overall	15 (60)	16 (73)	0.36
At least grade 2	7 (28)	5 (23)	0.68
ASAT increased, no. (%)
Overall	10 (40)	10 (45)	0.71
At least grade 2	3 (12)	4 (18)	0.69
Glutamyl transpeptidase increase,  no. (%)
Overall	19 (76)	16 (73)	0.80
At least grade 2	11 (44)	10 (45)	0.92

^aThe P values correspond to the statistics of Student's t test (baseline values) and of ANCOVA (week 24 values, the comparison being adjusted to baseline values) for quantitative variables and of the chi-square test or Fisher's exact test, when appropriate, for categorical variables. 

^bLipid measurements were not always obtained in a fasting state. However, to limit intraindividual variations, blood samples were collected for each patient at similar times along the follow-up and thus at similar intervals after food intake. 

^cALAT, alanine aminotransferase. 

^dASAT, aspartate aminotransferase.