The calculated coefficients of the prediction models and P-values obtained from the ANOVA test results ^a.

Term	RSDFX & DFP		RSDFP & IS		TFDFX		TFDFP		Run time
	Coef.	p-value	Coef.	p-value	Coef.	p-value	Coef.	p-value	Coef.	p-value
I	2.2582	0.0004*	2.5758	<0.0001*	1.3392	<0.0001*	1.4079	<0.0001*	7.0995	<0.0001*
X	−0.6521	0.0035*	−0.2156	0.0002*	0.0274	0.0793	0.0189	0.6373	−0.3714	0.0007*
Y	−0.2845	0.0748	0.0383	0.1502	0.0873	0.0010*	0.0655	0.1456	−0.0510	0.3653
Z	−1.1108	0.0003*	−0.5558	<0.0001*	−0.0110	0.4218	−0.0327	0.4289	−1.7230	<0.0001*
XY	0.00345	0.9815	−0.1088	0.0075*	−0.0156	0.3195	−0.0073	0.8706	−0.1928	0.0197*
XZ	0.30036	0.0868	−0.3592	<0.0001*	−0.0189	0.2373	0.0306	0.5025	0.3170	0.0026*
YZ	0.4524	0.0233*	−0.1058	0.0082*	0.0084	0.5737	0.0388	0.3988	−0.1304	0.0696
XYZ	−0.2328	0.1703	−0.3147	<0.0001*	−0.0344	0.0628	−0.0555	0.2590	−0.0788	0.2371
X 2	0.21398	0.4686	0.1648	0.0194*	−0.0385	0.2150	−0.0966	0.2912	−0.2631	0.0626
Y 2	−0.4120	0.1964	0.00303	0.9533	0.0279	0.3576	−0.0457	0.6054	0.2456	0.0792
Z 2	0.38952	0.2179	−0.1068	0.0823	−0.0405	0.2009	−0.0246	0.7786	0.6257	0.0025*

^aHighlighted values (bold) indicate significant effect on the corresponding response. Coef. = coefficient (slope), I = intercept, X = temperature, Y = pH, Z = % of organic solvent, Rs = resolution and TF = tailing factor.