Scheme 7. Reagents and conditions for the synthesis of PF403 starting from 12 with acetyl substitution at 3-position: (a) Ac2O, TEA, DMAP, DCM, r.t.; (b) NaBH4, then Et3SiH, BF3–Et2O, r.t.; (c) NaOH, CH3OH, r.t., then HCl; (d) Red-Al, THF, r.t.
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