Fig 3. Sensitivity of the optimal ratio to PKPD outcome choices and antibody features.

The optimal ratio was calculated for each parameter set and each outcome. A) Optimal ratios cluster by outcome similarly to the general analysis in Fig 2 with differences being that coverage and IIP can be grouped together whilst the minimum interaction model separates into 2 categories. B) Different variables drive optimization of different outcomes. Among viral pharmacodynamic inputs, the geometric mean IC50 is most influential on titer and minimum potency outcomes, while the fraction resistant is most influential for the remaining outcomes. C) A low percentage of parameter sets admitted outcomes within 95% of the optimal value.