TABLE 3.
Risk Factors for 28-Day All-Cause Mortality for 81 Children With Thrombocytopenia-Associated Multiple Organ Failure
| Risk Factors | Regression Coefficient |
se | Adjusted Relative Risk |
95% CI | p | % Reliabilitya |
|---|---|---|---|---|---|---|
| Standard multivariable analysis using modified Poisson regression | ||||||
| TPE | −0.7954 | 0.3506 | 0.45 | 0.23–0.90 | 0.02 | 61 |
| Baseline PELODb | 0.0519 | 0.0119 | 1.30 | 1.15–1.46 | < 0.001 | 99 |
| Extracorporeal membrane oxygenation | 0.2407 | 0.3229 | 1.27 | 0.68–2.40 | 0.46 | 17 |
| Continuous renal replacement therapy | 0.4663 | 0.3891 | 1.59 | 0.74–3.42 | 0.23 | 30 |
| Methicillin-resistant Staphylococcus aureus infection | 0.3044 | 0.2916 | 1.36 | 0.77–2.40 | 0.30 | 38 |
| Propensity score adjusted with propensity score specified as a continuous covariate | ||||||
| TPE | −0.7740 | 0.3808 | 0.46 | 0.22–0.97 | 0.04 | – |
| Baseline PELODb | 0.0487 | 0.0130 | 1.28 | 1.12–1.45 | < 0.001 | – |
| Propensity score adjusted with inverse probability of treatment weighting | ||||||
| TPE | −0.7775 | 0.3256 | 0.46 | 0.24–0.87 | 0.02 | – |
| Baseline PELODb | 0.0509 | 0.0142 | 1.29 | 1.12–1.48 | < 0.001 | – |
PELOD = Pediatric Logistic Organ Dysfunction, TPE = therapeutic plasma exchange.
a
Percentage of time risk factor appears in 1,000 bootstrap models. Risk factors appearing in at least 50% of models are reliable.
b
Adjusted relative risk and 95% CI reported per 5-point increase in baseline PELOD score. The reference category is no for TPE, extracorporeal membrane oxygenation, CVVH, and methicillin-resistant Staphylococcus aureus infection.
Dashes refer to that fact that the Reliability column applies only to the standard multivariable analysis using modified Poisson regression.