FIG. 2.

Susceptibilities to fluconazole and ketoconazole of the clinical C. dubliniensis isolates CM1 and CM2 and the heterozygous (CdM2) and homozygous (CdM4) mdr1 mutants derived from CM2. The MICs of the drugs for the isolates and their derivatives were determined by a broth microdilution method (see Materials and Methods). In this assay strains are defined as fluconazole susceptible if the MIC is <6.25 μg/ml, as intermediately susceptible if the MIC is ≥6.25 μg/ml to <25 μg/ml, and as resistant if the MIC is ≥25 μg/ml (12).