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. Author manuscript; available in PMC: 2022 May 9.
Published in final edited form as: Nat Protoc. 2021 Sep 10;16(10):4766–4798. doi: 10.1038/s41596-021-00596-0

Table 6.

Columns contained in scored data output from the dual-targeting scoring mode in Procedure 2, Steps 11 and 12 and Procedure 3, Step 4. SCREEN placeholders represent the names of all scored condition and control screens, whereas CONDITION and CONTROL placeholders represent the names of condition and control screens, respectively.

Scored data column Description
gene1 Gene symbol targeted by the first guide
gene2 Gene symbol targeted by the second guide
n_[SCREEN] Number of guides post-filtering for the screen
mean_[SCREEN] Mean LFC across all guides
variance_[SCREEN] Variance for all guides
differential_[CONDITION]_vs_[CONTROL] Loess-adjusted (if specified) differential between mean condition and control LFCs
pval_[CONDITION]_vs_[CONTROL] P-value between loess-adjusted residuals for condition and control
fdr_[CONDITION]_vs_[CONTROL] FDR-adjusted p-value
significant_[CONDITION]_vs_[CONTROL] Significance calls returned from call_significant_response
effect_type_[CONDITION]_vs_[CONTROL] Effect type calls returned from call_significant_response