Case 10 (prostate-specific antigen [PSA] 7.24 ng/ml; prostate volume 27 cm3). Isolated anterior 2.6-cm3 lesion suspicious at magnetic resonance imaging in the anterior fibromuscular stroma on the midline and anterior right transition zone lobe (arrows): (a) T2; (b) apparent diffusion coefficient map; (c) dynamic contrast-enhanced sequences. Targeted biopsies were positive for 8-mm Gleason score (GS) 7 (4 + 3) cancer. At histology, cancer was at the anterior and inferior part of the specimen: 4.61-cm3 volume, GS 7 (3 + 4), pT3a, pN0, and R1. Positive margins were anterior 6 mm and lateral 6 mm. Postoperative PSA was 0.41 ng/ml at 3 mo and 1.16 ng/ml at 18 mo postoperatively. Biopsies at left anterior part of preserved PZ showed residual cancer on 3 mm GS 6 (3 + 3). Radical prostatectomy was performed at 2 yr with negative margins and detectable PSA.