Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 25;13:858505. doi: 10.3389/fimmu.2022.858505

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Yu, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

A schematic diagram showing the domain architectures of SHARPIN, HOIP, and HOIL-1L proteins. Structures are shown where available and include the PH domain of SHARPIN (4EMO); HOIP PUB (4OYK), HOIP ZF/NEMO UBAN (4OWF), HOIL-1L UBL/HOIP UBA/SHARPIN UBL complex(5Y3T), HOIP RBR/UBE2D2-ubiquitin (5EDV) and the HOIL-1L NZF/linear diUb complex (3B08).The phosphorylation of Ser165 of SHARPIN can be involved in the activation of NF-κB. The phosphorylation of Ser146 of SHARPIN promotes the metastatic spread of cancer cells through an interaction with ARP2/3.