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. 2022 Apr 25;13:858505. doi: 10.3389/fimmu.2022.858505
Ub Ubiquitin
E1 Ub-activating enzyme
E2 Ub-conjugating enzyme
E3 Ub ligase
LUBAC The linear ubiquitin chain assembly complex
SHARPIN SHANK-associated RH domain-interacting protein
HOIP Ring finger protein 31
HOIL-1L RanBP-type and C3HC4-type zinc finger containing 1
cpdm chronic proliferative dermatitis mice
UBL ubiquitin-like domain
NZF Npl4-zinc finger domain
UBA ubiquitin-associated domain
RBR RING-between RING
PUB UBX-containing protein
ZF zinc finger
NZF Nlp4-like ZF domains
LDD linear Ub chain determining domain
NEMO Inhibitor of kappaB kinase gamma
NF-κB Nuclear factor kappa B
LTM LUBAC-tethering motif
TD Tethering domain
ATM ataxia telangiectasia mutated
IKKα Nuclear factor of kappa light polypeptide gene enhancer, alpha
IKKβ Nuclear factor of kappa light polypeptide gene enhancer,beta
Eya1 Eyes absent 1 protein
BOR Branchio-oto-renal
TNF tumor necrosis factor
TRADD TNFR1-associated death domain protein
TRAF2 TNF receptor-associated factor 2
cIAPs cellular inhibitor of apoptosis
RIPK1 receptor interacting protein kinase 1
PTEN phosphatase and tensin homolog
PTEN-NRs negative regulatory protein of PTEN
SIPL1 class SHANK interacting protein 1
PIP3 phosphorylation of 3 phosphate
ERα estrogen receptor alpha
MDM2 (mouse double minute 2 homolog
Rap1 Ras-associated protein-1
Pvhl Von Hippel-Lindau protein
HIF hypoxia-induced factor
PHD prolyl hydroxylase domain-containing protein
AD Alzheimer’s disease
amyloid-beta
LOAD late-onset Alzheimer’s disease