Author response image 2. We looked at the correlation between order parameters and the inhibitor constant (Ki) of binding for the five CDK2 protein-inhibitor complexes we had data for.

We did not observe any trends in this data. (A) The difference in average binding site order parameters (holo-apo) are not correlated with the inhibitory constant (Ki) of binding. (B) The average order parameter of the holo binding site residues are not correlated with the inhibitory constant (Ki) of binding. (C) The relationship between the residual order parameter (Distant Residues – Binding Site Residues).