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. Author manuscript; available in PMC: 2023 Apr 25.
Published in final edited form as: Angew Chem Int Ed Engl. 2022 Mar 9;61(18):e202117233. doi: 10.1002/anie.202117233

Table 3.

Scope of Ketones[a]

graphic file with name nihms-1778135-t0005.jpg
[a]

Conditions: 4 (0.25 mmol, 2.5 equiv), 2a (0.1 mmol, 1.0 equiv), Pd(OAc)2 (10 mol %), TDG1 (30 mol %), L4 (50 mol %), Ag3PO4 (70 mol %), CsOAc (1.0 equiv.), HFIP (0.6 mL), 100 °C, under air, 24‒48 h.

[b]

The ratio of r.r. was determined by 1H NMR analysis of the crude reaction mixture.

[c]

2% di-arylation product on β-tertiary and γ-methylene C-H bonds was observed.

[d]

A trace amount of methylene C‒H activation product was observed