FIG. 6.

Activity of P-113d against endogenous P. aeruginosa in undiluted sputum. Fresh sputum was incubated for 1 h at 37°C with or without 50 μg of rhDNase per ml, as indicated, and for a second hour at 37°C with 100 μg of P-113d per ml. For each experiment the survival was the percentage of the number of CFU compared to that for sputum incubated for 2 h at 37°C in the absence of P-113d, as described in Materials and Methods. Error bars indicate the standard deviations from the means for three experiments. ■, no pretreatment with rhDNase; ▨, pretreatment with rhDNase.