Table 2. Univariate and multivariate time-dependent Cox regression analyses for OS and metastasis-free survival according to risk factors in all patients after matching by T, N and neoadjuvant chemotherapy (n = 210).

OS
	Univariate		Multivariate
Factor	HR (95% CI)	p	HR (95% CI)	p
Lymphovascular invasion
Absent	1		1
Present	2.411 (1.379–4.214)	0.002	2.292 (1.307–4.023)	0.004
T
T1	1
T2	1.681 (0.649–4.354)	0.285
T3	2.468 (0.893–6.818)	0.082
T4	2.559 (0.865–7.566)	0.089
N
N0	1		1
N1	1.397 (0.765–2.552)	0.276	1.404 (0.766–2.572)	0.273
N2	1.949 (0.930–4.087)	0.077	2.960 (1.377–6.360)	0.005
N3	11.314 (3.125–40.970)	<0.0005	6.798 (1.827–25.301)	0.004
Histological grade
G1/G2	1		1
G3	2.431 (1.431–4.130)	0.001	2.085 (1.189–3.656)	0.010
Molecular subtype
Luminal A	1		1
Luminal B	1.675 (0.762–3.681)	0.199	1.193 (0.530–2.685)	0.671
HER2	1.083 (0.417–2.816)	0.870	0.680 (0.247–1.871)	0.455
Triple-negative	4.718 (2.165–10.281)	<0.0005	2.085 (1.189–3.656)	0.010
DMFS
Lymphovascular invasion
Absent	1		1
Present	2.584 (1.455–4.588)	0.001	2.305 (1.294–4.103)	0.005
T
T1	1
T2	1.825 (0.691–4.823)	0.225
T3	2.795 (1.007–7.755)	0.048
T4	3.359 (1.135–9.942)	0.029
N
N0	1		1
N1	2.279 (1.183–4.387)	0.014	2.267 (1.170–4.393)	0.015
N2	3.076 (1.373–6.892)	0.006	3.377 (1.477–7.725)	0.004
N3	3.267 (0.716–14.912)	0.127	3.139 (0.655–15.033)	0.152
Histological grade
G1/G2	1		1
G3	2.155 (1.252–3.709)	0.006	1.738 (0.986–3.061)	0.056
Molecular subtype
Luminal A	1		1
Luminal B	1.927 (0.805–4.614)	0.141	1.451 (0.591–3.565)	0.417
HER2	2.201 (0.853–5.680)	0.103	1.603 (0.599–4.294)	0.347
Triple-negative	5.105 (2.140–12.182)	<0.0005	4.093 (1.674–10.088)	0.002

G1 – well differentiated; G2 – moderately differentiated; G3 – poorly differentiated; N – lymph node metastasis; T – tumour size