Table 5. Univariate and multivariate Cox regression analyses for OS and metastasis-free survival according to risk factors and treatments in patients of adjuvant schema (n = 304).

OS
	Univariate		Multivariate
Factor	HR (95% CI)	p	HR (95% CI)	p
Lymphovascular invasion
Absent	1		1
Present	3.597 (1.878–6.890)	0.002	2.656 (1.331–5.299)	0.006
T
T1	1		1
T2	2.865 (1.378–5.957)	0.005	2.543 (1.197–5.405)	0.015
T3	1.281 (0.346–4.749)	0.711	0.590 (0.149–2.335)	0.453
T4	10.653 (3.536–32.093)	<0.005	6.513 (1.972–21.513)	0.002
N
N0/N1	1		1
N2/N3	3.316 (1.885–5.833)	<0.0005	1.995 (1.052–3.782)	0.034
Histological grade
G1/G2	1		1
G3	2.177 (1.191–3.980)	0.011	1.868 (0.955–3.652)	0.068
Molecular subtype
Luminal A	1		1
Luminal B	2.679 (1.249–5.748)	0.011	2.591 (1.177–5.706)	0.018
HER2	2.452 (0.971–6.196)	0.058	1.134 (0.374–3.433)	0.825
Triple-negative	3.045 (1.236–7.502)	0.015	4.029 (1.519–10.688)	0.005
Systemic treatment
No	1		1
Yes	0.558 (0.308–1.013)	0.055	0.532 (0.238–1.190)	0.124
Radiotherapy
No	1		1
Yes	0.915 (0.329–2.542)	0.864	1.222 (0.401–3.721)	0.724
DMFS
Lymphovascular invasion
Absent	1		1
Present	4.369 (2.236–8.535)	0.001	2.815 (1.333–5.941)	0.007
T
T1	1
T2	2.297 (1.163–4.539)	0.017
T3	1.106 (0.308–3.975)	0.877
T4	6.364 (2.014–20.110)	0.002
N
N0	1		1
N1	3.030 (1.470–6.247)	0.003	2.200 (1.019–4.749)	0.045
N2/N3	7.720 (3.787–15.737)	<0.0005	4.451 (2.001–9.904)	0.004
Histological grade
G1/G2	1
G3	1.525 (0.797–2.919)	0.203
Molecular subtype
Luminal A	1		1
Luminal B	2.316 (1.106–4.849)	0.026	2.589 (1.195–5.608)	0.016
HER2	2.391 (0.993–5.760)	0.052	1.069 (0.388–2.943)	0.897
Triple-negative	2.118 (0.835–5.373)	0.114	2.996 (1.160–7.739)	0.023
Systemic treatment
No	1		1
Yes	0.456 (0.253–0.822)	0.009	0.430 (0.198–0.936)	0.033
Radiotherapy
No	1		1
Yes	0.536 (0.212–1.355)	0.188	0.407 (0.155–1.071)	0.069

G1 – well differentiated; G2 – moderately differentiated; G3 – poorly differentiated; N – lymph node metastasis; T – tumour size