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. 2022 Apr 26;14(8):3554–3568. doi: 10.18632/aging.204029

Figure 1.

Figure 1

Decreased claudin-5 level in AD and elder mice. (A, B) The APP/PS1 mice exhibited increased Aβ protein level in hippocampal region (n = 4 per group; two-tailed Student’s t-test). (C, D) Decreased claudin-5 protein level in hippocampus of the APP/PS1 mice (n = 4 per group; two-tailed Student’s t-test). (E) Decreased claudin-5 mRNA level in hippocampus of APP/PS1 mice (n = 6 per group; two-tailed Student’s t-test). (F, G) The elder mice exhibited increased Aβ protein level in hippocampal region (n = 4 per group; two-tailed Student’s t-test, P = 0.001). (H, I) Decreased claudin-5 protein level in hippocampus of elder mice (n = 4 per group; two-tailed Student’s t-test). (J) Decreased claudin-5 mRNA level in hippocampus of elder mice (n = 6 per group; two-tailed Student’s t-test). Data show mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001.