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. 2022 Apr 26;14(8):3554–3568. doi: 10.18632/aging.204029

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Copyright: © 2022 Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Effects of knockout of claudin-5 on glutamatergic transmission in hippocampal slices. (A) I-O curves in claudin-5^+/− mice and their control littermates (n = 6 per group; repeated measures two-way ANOVA). (B) PPF in claudin-5^+/− mice and their control littermates (n = 6 per group; repeated measures two-way ANOVA). (C–E) sEPSCs recording in claudin-5^+/− mice and their control littermates. Average sEPSC frequency (Hz) in (D) and amplitude in (E) were obtained (n = 9 per group; two-tailed Student’s t-test). Scale bars: 20 pA, 2 s. (F) NMDAR fEPSPs slopes in claudin-5^+/− mice and their control littermates (n = 6 slices/group; repeated measures two-way ANOVA). The fEPSPs were recorded in the presence of 20 μM CNQX and 0 nM Mg²⁺. (G, H) NMDA currents recording in claudin-5^+/− mice and their control littermates (n = 9 per group; two-tailed Student’s t-test). Scale bars: 50 pA, 100 ms. Data show mean ± s.e.m.