Table 2.
List of the published clinical trials that highlight the application of silk-based materials.
| No. | Intervention/treatment | Condition/disease | Number of participants | Compete date | Clinical trial identifier |
|---|---|---|---|---|---|
| 1 | Device: The SF patch or paper patch | Diseases of the ear and mastoid process | 60 | June 2012 | KCT0000305 |
| 2 | Device: HQ® matrix medical wound dressing Device: Sidaiyi® wound dressing |
Donor site wound | 71 | September 2014 | NCT01993030 |
| 3 | Device: silk fibroin with bioactive coating layer dressing | Late complication from skin graft; infection of skin donor site; impaired wound healing; pain, intractable |
29 | May 2015 | NCT02091076 |
| 4 | Bilayer scaffold composed of amniotic membrane and silk fibroin | Diabetes mellitus; Wagner ulcer grade II | 20 | February 2018 | IRCT2016071328903N1 |
| 5 | Absorbable SF membrane | Alveolar ridge preservation after tooth extraction | 65 | December 2018 | ChiCTR1800016759 |
| 6 | Autologous chondrocytes seeded in SF scaffolds | Osteochondral defects | 15 | July 2019 | IRCT2017062434731N1 |
| 7 | SF membrane combined with xenograft | K053-chronic periodontitis | 15 | December 2019 | CTRI/2018/12/016509 |
| 8 | Serioss® (SF scaffold) | Patients undergoing surgery for bone void filling | 10 | / | CTRI/2021/01/030589 |
| 9 | Device: Silk Bridge | Peripheral nerve injury digital nerve hand | 4 | March 2021 | NCT03673449 |
| 10 | Silk sericin dressing with collagen | Wound heal; wound surgical; donor site complication | 30 | December 2021 | NCT04743375 |
| 11 | Procedure: Silk microparticle filler injection | Vocal cord paralysis unilateral; dysphonia; dysphagia, oropharyngeal | 100 | September 2024 | NCT03790956 |
Source: data retrieved from International Clinical Trials Registry Platform.