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. 2022 May 2;2022:2948578. doi: 10.1155/2022/2948578

Figure 5.

Figure 5

miR-146a-5p modulates macrophage polarization. (a) The expression level of miR-146a-5p after miR-146a-5p mimic, miR-146a-5p inhibitor, miRNA mimic NC, and inhibitor NC transfected in RAW264.7 macrophages. (b)–(d) The expression level of Arg1, IL4RA, IL-10, IL-6, IL-1, CCL2, CCL3, VEGFA, TNFα, and iNOS in macrophages with miR-146a-5p mimic, miR-146a-5p inhibitor, miRNA mimic NC, and inhibitor NC treatment. (e)–(f) The protein levels of TRAF6 and phosphorylated IKKα/β in macrophages with different treatments. (g) Transwell migration assays. (h) Statistics of the number of migrated cells; scale bar = 50 μm. mimic NC: miRNA mimic negative control group; mimic: miR-146a-5p mimic group; inhibitor NC: miRNA inhibitor negative control group; inhibitor: miR-146a-5p inhibitor group. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.