Pharmacokinetic parameters of EMPA, MET and CANA after oral administration of a fixed-dose combination Invokamet tablet (50 mg CANA/500 mg MET) and a single dose of Jardiance tablet (EMPA 25 mg)a.
| Pharmacokinetic parameters | Mean ± SD | ||
|---|---|---|---|
| CANA | MET | EMPA | |
| T max (h) | 3.2 ± 0.3 | 4.1 ± 0.5 | 2.9 ± 0.3 |
| C max (ng mL−1) | 390.4 ± 50.2 | 859.7 ± 91.2 | 215.6 ± 44.1 |
| AUC0–24 (ng h mL−1) | 3862.8 ± 426.9 | 6627.1 ± 699.3 | 1398.7 ± 122.5 |
| AUC0–∞ (ng h mL−1) | 3973.6 ± 508.5 | 7022.8 ± 703.6 | 1426.0 ± 150.8 |
| T 1/2 (h) | 12.1 ± 1.4 | 6.3 ± 0.8 | 7.2 ± 1.1 |
a
T max: Time required for reaching maximum plasma concentration, Cmax: maximum plasma concentration, AUC0–24: area under curve, AUC0–∞: area under curve at infinite time, T1/2 (h): time required for reaching to half concentration.