TABLE 2.
Top 10 genes for classifying the subjects into fast episodic memory decline and slow episodic memory decline and top 10 genes predictive of episodic memory in the full cohort.
Gene symbol | z-score | Direction* | Gene symbol | z-score | Cor.* |
PRTN3 | 7.47 | Down | PRTN3 | 7.45 | + |
ADAMTS2 | 6.22 | Up | ADAMTS2 | 6.83 | − |
PPM1D | 5.92 | Up | ZCCHC10 | 6.43 | + |
ENSG00000216895 | 5.3 | Down | TAF1D | 6.3 | + |
LINC02172 | 5.18 | Up | CCN4 | 5.76 | − |
SLC6A9 | 4.95 | Up | ZNF334 | 5.59 | + |
TMEM72-AS1 | 4.88 | Down | HMGN2 | 5.48 | + |
PPP4R1 | 4.8 | Up | PPP4R1 | 5.47 | − |
QDPR | 4.57 | Up | SLC4A11 | 4.99 | − |
ZNF334 | 4.56 | Down | ANKRD19P | 4.96 | + |
*Higher or lower mean expression in dementia.
*Pearson correlation between gene and slope of episodic memory decline.