TABLE 2.
Reduction of A. fumigatus kidney burden with caspofungin or AmB treatmenta
| No. of days postinfection | Log10 CE/g of kidney
|
|||
|---|---|---|---|---|
| Caspofungin treated
|
AmB treated
|
|||
| Standard assay | Modified assay | Standard assay | Modified assay | |
| 1 | 4.29 ± 0.12 | NDb | 4.12 ± 0.23 | ND |
| 15 | 3.30 ± 0 | 3.13 ± 0.38 | 3.31 ± 0.01 | 3.34c |
| 21 | 3.30 ± 0 | 2.25 ± 0.13 | 3.30 ± 0 | 2.60 ± 0.15 |
| 28 | 3.30 ± 0 | 2.07 ± 0.37d | 4.41 ± 1.11 | 3.38 ± 1.63 |
| 35 | 3.30 ± 0 | 2.12 ± 0.19 | 3.30 ± 0e | 2.54 ± 0.08e |
a
Values represent mean log10 CE per gram of kidney ± standard error from three animals unless noted otherwise. Standard assay results are also shown in Fig. 4B. The limit of detection for the standard assay is 3.30 log10 CE/g of kidney. In the modified assay, evaluation was performed at a lower limit of assay detection. The limit of detection for the modified assay is 1 conidium per 19.6 mg of tissue, or 1.70 log10 CE/g of kidney.
b
ND, not determined.
c
Sufficient homogenate from one of three animals.
d
Sufficient homogenate from two of three animals.
e
Only two mice remaining at 35 days postinfection.