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. 2018 Sep 5;8(54):31201–31212. doi: 10.1039/c8ra06691d

Cytotoxic activities of genistein and its amino acid derivatives 4a–4d.

Compounds Cancer cell lines (IC50, μM)a
MCF-7 Hela MGC-803 HCT-116
4a >100 66.63 ± 3.60 24.35 ± 1.27 65.28 ± 2.91
4b 21.32 ± 2.24 90.27 ± 0.47 12.08 ± 0.06 >100
4c 99.73 ± 0.11 82.71 ± 0.15 33.53 ± 0.13 42.64 ± 0.15
4d 47.00 ± 3.53 68.14 ± 1.05 35.35 ± 3.72 92.87 ± 0.04
Genistein >100 >100 >100 >100
a

Each value represents mean ± SD of three experiments.