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. 2022 Apr 21;12:850744. doi: 10.3389/fcimb.2022.850744
U-exo small extracellular vesicles derived from human umbilical cord mesenchymal stem cells
IFV human influenza A/B virus
HCoV human seasonal coronavirus
IFN-α interferon-alpha protein
ALI air-liquid interface
SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
MERS-CoV middle east respiratory syndrome coronavirus
SARS-CoV-1 severe acute respiratory syndrome coronavirus 1
EVs extracellular vesicles
miRNAs microRNAs
MSCs mesenchymal stem cells
HCV Hepatitis C virus
UCMSCs umbilical cord-derived mesenchymal stem cells
HNECs primary human nasal epithelial cells
A549 human lung adenocarcinoma cells
HCT8 human colorectal adenocarcinoma cells
MRC5 human lung embryonic fibroblast cells
NS1 non-structural protein 1
IFV-PR8delNS1 Human influenza virus A/Puerto-Rico/8/34 PR8 lacking NS1
MOI multiplicity of infection
TCID50 tissue culture infectious dose
hpi hours post-infection
NTA Nanoparticle Tracking Analysis
TEM transmission electron microscopy
MTT 3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide
LDH lactate dehydrogenase
GAPDH Glyceraldehyde 3-phosphate dehydrogenase
DAPI 4,6-diamidino-2-phenylindole
TEER trans-epithelial electrical resistance
H&E hematoxylin and eosin
CM Conditioned medium
HBV Hepatitis B virus
sEVs small EVs
RLR retinoic acid-inducible gene I-like receptors
RIG-I retinoic acid-inducible gene-I
MDA5 melanoma differentiation associated gene 5
MAVS mitochondrial antiviral signaling protein
STING stimulator of interferon response c-GAMP interactor 1
Mx1 MX dynamin like GTPase 1
ISG15 interferon-stimulated gene 15
OAS1 2’-5’-oligoadenylate synthetase 1
IFITM3 interferon induced transmembrane protein 3
IFN-β interferon-beta
IFN-λ1 interferon-lambda 1
ISGs interferon-stimulated genes
JAK/STAT Janus kinase/signal transduction and activator of transcription signaling pathways