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. 2022 Apr 6;33(6):831–841. doi: 10.1007/s10552-022-01574-x

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© The Author(s) 2022

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Fig. 2 — Barbadian and Nigerian women with TNBC harbour different genetic alterations than European American (EA)and African American (AA) women with TNBC. A Global analysis of all altered genes revealed that only 78 genes are shared among the four groups (Barbadian, Nigerian, TCGA-TNBC-EA, TCGA-TNBC-AA) and 2,401 genes are unique to the EA group in comparison to the other cohorts. B Global comparison of variants with TCGA-TNBC-EA group identified 2 pseudogenes (TNRC18P2 and DDX12P) with an increase in variant frequency in the Nigerian (n = 12) and Barbadian (n = 19) cohorts. Benjamini–Hochberg tests used for multiple testing. C Genes with high frequency variants in Barbadian and Nigerian samples were not enriched in the TCGA dataset except for TP53 (third gene from the top of the gene list)