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. 2022 Apr 6;33(6):831–841. doi: 10.1007/s10552-022-01574-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Mutation signature contributions for Barbadian and Nigerian TNBC samples show high correlation to COSMIC Signatures 1, 3 and 6. Using COSMIC somatic mutation signatures, Age, BRCA1/BRCA2 and Defective DNA MMR/MSI (small INDELS) were enriched signatures for Barbadian and Nigerian samples. These signatures were also enriched in TCGA-AA, TCGA-EA women with TNBC and overall, all breast cancer cases within TCGA