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. 2022 May 9;13:2522. doi: 10.1038/s41467-022-30240-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Total bacterial DNA was isolated from the intestinal content, and 16S rRNA genes were sequenced. a The diversity and richness of the gut microbiota in AML patients (AML) and healthy controls (Con). Unpaired t-tests were used to compare the Shannon index (n = 61). Data were presented as standard boxplots (with the box encompassing Q1–Q3, the median denoted as a central horizontal line in the box, and the whiskers covering the data within ±1.5 IQR). b PCoA of a weighted UniFrac distance analysis (n = 61). c Relative taxon abundance comparison among the AML and control groups (n = 61). d Spearman correlations between the intestinal content of the 10 genera in AML patients and healthy controls. Faecalibacterium and Roseburia were significantly correlated (red positive correlation, blue negative correlation). e Cladogram generated from linear discriminant analysis effect size (LEfSe) and the LDA score. f The abundance of Faecalibacterium and OTUs was reduced in the unfavourable-risk group (n = 20) compared with the favourable-risk group (n = 9). P values were determined using two-tailed t-test in (a, f) and using Wilcoxon rank test in c. Error bars represent mean ± SEM in (a, c, f). *P = 0.02178 (a), **P = 0.0016, *P = 0.015 (f). Source data are provided as a Source Data file.