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. 2022 May 9;12:7583. doi: 10.1038/s41598-022-11596-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dose and time course experiment of Jagged1 promotes Wnt related gene expression in hDPSCs. Correlation of Notch and Wnt pathways. (a) The mRNA levels of Notch-related genes (HES1 and HEY1) and Wnt-related genes (WNT2B, WNT5A, WNT5B, WNT16, DKK1, DKK2, and SOST) were measured using real-time polymerase chain reaction after exposed to different Jagged1 concentrations for 24 h. (b) The mRNA expression of hDPSCs treated with 10 nM Jagged1 was evaluated at day 1, 3, and 7. Bars indicate a significant difference between groups (p < 0.05).