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. 2022 May 9;12:7583. doi: 10.1038/s41598-022-11596-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IWP-2 attenuates the osteo/odontogenic differentiation induced by Jagged1. Cells were pretreated with DKK1 or IWP-2 30 min prior to seeding on Jagged1 surfaces and further maintain in osteo/odontogenic induction medium. (a and d) ALP enzymatic activity and mineral deposition was examined at day 7 and 14, respectively. (b and e) The solubilized alizarin red s staining was measured and quantitated. (c and f) The mRNA levels of osteo/odontogenic marker genes were measured using real-time polymerase chain reaction. Bars indicate a significant difference between groups (p < 0.05).