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. 2022 May 9;13:2539. doi: 10.1038/s41467-022-30195-w

Fig. 2. Bone loss in the tibias and lumbar vertebrae after SARS-CoV-2 infection in the golden Syrian hamster model.

Fig. 2

a Representative μCT image showing the reduction in trabecular bone volume in tibias of the SARS-CoV-2-infected hamsters. b Corresponding measurements of BV/TV, BMD of TV, Tb.Th, Tb.Pf, BS/BV, and pMOI. Mock: n = 11 (D4), 8 (D30), 8 (D60); Infected: n = 10 (D4), 12 (D30), 6 (D60). c Representative H&E staining images showing the cancellous bone structures in tibias of the SARS-CoV-2-infected hamsters (n = 4, scale bars = 500 µm). d Representative μCT and corresponding H&E staining images showing the bone loss in the lumbar vertebrae of the SARS-CoV-2-infected hamsters. e Corresponding measurements of BV/TV, BMD of TV, Tb.Th, Tb.Pf, BS/BV, and pMOI. Mock: n = 6 (D4), 6 (D30); Infected: n = 8 (D4), 6 (D30). Data were presented as box plots with whiskers from minima to maxima, the central line at the 50th percentile, and the ends of the box at the 25th and 75th percentiles. *P < 0.05, **P < 0.01 by two-way ANOVA with Bonferroni’s multiple comparisons test.