TABLE 5.
Noncompartmental pharmacokinetic parameters of high-dose L-AMB
| Dosage (mg/kg/day) | Day | n | Cmax (μg/ml) | AUC24 (μg · h/ml) | AUC∞ (μg · h/ml) | t1/2 (h) | CL (ml/h/kg) | V (liter/kg) | Vss (liter/kg) | MRT (h) |
|---|---|---|---|---|---|---|---|---|---|---|
| 7.5 | 1 | 8 | 75.9 ± 58.4 | 692 ± 834 | 815 ± 1068 | 6.8 ± 1.9 | 23 ± 14 | 0.22 ± 0.18 | 0.24 ± 0.18 | 10.7 ± 2.6 |
| 7 | 6 | 115.1 ± 104.9 | 1,333 ± 2,153 | 1,670 ± 2,868 | 6.0 ± 0.8 | 15 ± 11 | 0.14 ± 0.10 | 0.14 ± 0.11 | 8.7 ± 1.2 | |
| La | 4 | 144.3 ± 61.6 | 1,286 ± 973 | 1,498 ± 1,040 | 6.5 ± 3.4 | 11 ± 13 | 0.08 ± 0.08 | 0.18 ± 0.12 | 11.9 ± 4.4 | |
| 10 | 1 | 7 | 119.6 ± 69.8 | 1,062 ± 971 | 1,188 ± 1,058 | 8.0 ± 1.5 | 18 ± 19 | 0.23 ± 0.24 | 0.22 ± 0.23 | 12.3 ± 1.8 |
| 7 | 6 | 164.7 ± 119.7 | 1,919 ± 2,056 | 2,156 ± 2,221 | 8.4 ± 2.6 | 12 ± 12 | 0.16 ± 0.17 | 0.14 ± 0.14 | 12.8 ± 3.0 | |
| L | 4 | 208.9 ± 47.7 | 1,944 ± 592 | 2,431 ± 942 | 10.5 ± 6.6 | 5 ± 3 | 0.05 ± 0.03 | 0.06 ± 0.03 | 14.3 ± 7.1 | |
| 12.5 | 1 | 7 | 116.3 ± 47.8 | 860 ± 390 | 902 ± 450 | 7.1 ± 3.5 | 16 ± 6 | 0.18 ± 0.13 | 0.16 ± 0.07 | 9.8 ± 1.1 |
| 7 | 5 | 147.4 ± 69.2 | 1168 ± 911 | 1,292 ± 1,010 | 8.2 ± 2.5 | 13 ± 7 | 0.16 ± 0.10 | 0.13 ± 0.08 | 9.8 ± 1.1 | |
| L | 1 | 754.8 | 13,919 | 46,558 | 48 | 0.3 | 0.07 | 0.09 | —b | |
| 15 | 1 | 11 | 105.1 ± 30.9 | 554 ± 174 | 685 ± 252 | 9.0 ± 3.1 | 25 ± 8 | 0.33 ± 0.12 | 0.23 ± 0.09 | 9.1 ± 2.8 |
| 7 | 6 | 178.6 ± 49.0 | 1,152 ± 617 | 1,355 ± 693 | 9.0 ± 0.9 | 14 ± 7 | 0.18 ± 0.09 | 0.14 ± 0.06 | 10.2 ± 1.6 | |
| L | 2 | 231 | 2,168 | 2,300 | 8.5 | 9 | 0.14 | 0.12 | 10.9 |
a
L, last.
b
—, Insufficient data to determine MRT.