TABLE 1.
Pearson correlation analysis of the top three modules (including acylcarnitines and amino acids) and the blood gene expression data in Alzheimer's Disease Neuroimaging Initiative
| Gene Expression (N = 17,849) | Topmetabolite modules | Rho value | P‐value | P.adj |
|---|---|---|---|---|
|
CPT1A (Carnitine Palmitoyltransferase 1A) |
M6 | 0.317 | 3.50 × 10−11 | 1.87 × 10−6 |
|
SLC25A20 (Carnitine/Acylcarnitine Translocase) |
M6 | 0.261 | 6.60 × 10−8 | 1.8 × 10−3 |
|
ABCA1 (ATP Binding Cassette Subfamily A Member 1) |
M8 | −0.236 | 1.10 × 10−6 | .02 |
| MRPL47 | M3 | 0.233 | 1.50 × 10−6 | .02 |
| ABCA1 | M3 | −0.23 | 2.10 × 10−6 | .02 |
| ABCG1 | M3 | −0.222 | 4.90 × 10−6 | .038 |
| PDK4 | M6 | 0.222 | 4.60 × 10−6 | .038 |
| UCHL3 | M3 | 0.22 | 5.80 × 10−6 | .039 |
| CCT2 | M3 | 0.215 | 9.10 × 10−6 | .049 |
| ABCG1 | M8 | −0.216 | 8.80 × 10−6 | .049 |
Note: The module M6 includes medium/long‐chain acylcarnitines, while the modules M8 and M3 include short‐chain acylcarnitines and amino acids, respectively.