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. 2022 Apr;13(2):695–709. doi: 10.21037/jgo-22-237

Figure 4.

Figure 4

miRNA-320 inhibits cell migration and invasion. (A,B) Representative images of the wound healing assay revealed that ectopic expression of miRNA-320 inhibited cell migration in HT29 and SW480 cells (A), while downregulation of miRNA-320 promoted cell migration in HCT116 and DLD1 cells (B). Observe and take pictures under an inverted microscope. Magnification, 40×. The width of black dashed lines indicates the initial wound area. The width of red dashed lines indicates the wound area after 48 hours (C,D) Representative images of the transwell assay (stained with 0.1% crystal violet) revealed that ectopic expression of miRNA-320 inhibited cell invasion of HT29 and SW480 cells (C), while downregulation of miRNA-320 promoted cell invasion of HCT116 and DLD1 cells (D). Magnification, 40×. Data are expressed as the mean ± SD. ***, P<0.001. LV, lentiviral vector; miRNA, microRNA; SD, standard deviation.