Table 2.

Group means of mood subscales across CSF ratio biomarkers

POMS	p-Tau/Aβ42
	+		−		p
	LSM	95% CI	LSM	95% CI
TMD	−4.06	(−5.80, −2.33)	−5.58	(−6.77, −4.39)	0.1598
Anxiety	33.09	(32.39, 33.79)	31.97	(31.49, 32.45)	0.0107
Depression	32.94	(32.48, 33.41)	32.46	(32.14, 32.78)	0.0950
Anger	36.67	(36.39, 36.97)	36.25	(36.06, 36.45)	0.0171
Vigor	59.78	(57.94, 61.61)	58.75	(57.50, 60.00)	0.3670
Fatigue	33.21	(32.31, 34.09)	32.08	(31.47, 32.69)	0.0426
Confusion	38.41	(37.74, 39.09)	37.71	(37.25, 38.17)	0.0916
GDS	0.999	(0.785, 1.121)	1.023	(0.710, 1.336)	0.9025
NPIQ	0.770	(0.573, 0.966)	0.852	(0.562, 1.143)	0.6448
	Aβ42/Aβ40
	+		−		p
	LSM	95% CI	LSM	95% CI
TMD	−4.57	(−6.16, −2.98)	−5.42	(−6.68, −4.17)	0.4121
Anxiety	32.81	(32.17, 33.46)	32.03	(31.52, 32.54)	0.0627
Depression	32.79	(32.36, 33.22)	32.51	(32.17, 32.84)	0.3080
Anger	36.64	(36.38, 36.90)	36.23	(36.03, 36.44)	0.0158
Vigor	59.72	(58.04, 61.40)	58.68	(57.36, 60.00)	0.3419
Fatigue	32.79	(31.97, 33.561	32.23	(31.58, 32.87)	0.2669
Confusion	38.21	(37.59, 38.83)	37.76	(37.27, 38.25)	0.2639
GDS	1.005	(0.778, 1.231)	1.010	(0.725, 1.296)	0.9749
NPIQ	0.777	(0.570, 0.985)	0.826	(0.561, 1.091)	0.7793
	t-Tau/Aβ42
	+		−		p
	LSM	95% CI	LSM	95% CI
TMD	−4.06	(−5.73, −2.38)	−5.64	(−6.85, −4.43)	0.1325
Anxiety	32.88	(32.20, 33.56)	32.04	(31.55, 32.53)	0.0507
Depression	32.96	(32.51, 33.41)	32.44	(32.11, 32.76)	0.0663
Anger	36.58	(36.31, 36.86)	36.29	(36.09, 36.49)	0.0930
Vigor	59.21	(57.44, 60.97)	59.01	(57.73, 60.29)	0.8593
Fatigue	33.10	(32.24, 33.95)	32.09	(31.47, 32.71)	0.0637
Confusion	38.29	(37.64, 38.94)	37.75	(37.28, 38.22)	0.1891
GDS	1.006	(0.789, 1.225)	1.007	(0.789, 1.309)	0.9966
NPIQ	0.786	(0.585, 0.986)	0.815	(0.537, 1.093)	0.8692

Abbreviations: POMS = Profile of Mood States; LSM = Least Squares Means; TMD = Total Mood Disturbance; GDS = Geriatric Depression Scale; NPIQ = Neuropsychiatric Inventory Questionnaire

Bold = <.05; Italics = marginally significant; 95% CI = 95% Confidence Interval;