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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Curr Opin Virol. 2022 Jan 11;53:101198. doi: 10.1016/j.coviro.2021.12.014

Figure 1. Potential approaches for modulating host genes as host-directed antiviral strategies.

Figure 1.

Schematic detailing various RNA-based strategies for the upregulation of host restriction factors (top) or the downregulation of host-dependency factors (bottom) to control viral infections. Abbreviations: crRNA, CRISPR RNA; CSE, alphavirus conserved sequence element; dCas9, nuclease-dead Cas9; RdRp, alphavirus RNA-dependent RNA polymerase; sgRNA, single guide RNA; siRNA, small interfering RNA.