FIGURE 5.

Inhibition of the LH2 constrains TNBC cell migration primarily through glycolysis modulation. (A–B) mRNA expression of glycolytic enzymes including PGK1, LDHA, PFKFB, PKM2, and PGAM in the MDA-MB-231 or BT-549 cells after LH2 silencing. (C–F) Representative images of the MDA-MB-231 or BT-549 cells treated with 2-DG (5 mM) or not after LH2 silencing. All the results were representative of three independent experiments. 10 × scale bars, 200 μm **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. the control or nc cells.