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. 2022 Apr 26;13:875128. doi: 10.3389/fgene.2022.875128

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Copyright © 2022 Li, Chen, Li, Yang, Wang, Dong, Mi, Zhang, Wang, Wang, Rodriguez, Tian and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the relationship between hub genes in HR and tumor progression and gene mutation. (A), Heatmap of correlation between hub genes and signature scores of core biological functions; (B–J), Correlation diagram between hub gene and the signature scores of core biological functions with moderate correlation; (K,L), Hub gene expression levels in TP53, RB1 gene mutation, and non-mutation samples distribution. (M,N), Distribution of hub gene expression levels in high and low TMB and TNB samples. HR, homologous recombination; TMB, Tumor mutation burden; TNB, tumor neoantigen burden.