TABLE 3.

Univariate Cox regression analysis.

Characteristic	Beta	Hazard ratio (95% CI for HR)	p Value
Sex	−0.17	0.84 (0.6–1.2)	3.10E-01
IC level	−0.34	0.71 (0.59–0.85)	2.10E-04	***
TC level	−0.03	0.98 (0.8–1.2)	8.10E-01
TMB	−0.05	0.96 (0.93–0.98)	3.10E-04	***
TNB	−0.36	0.7 (0.59–0.83)	6.10E-05	***
Lund2	0.19	1.2 (1.1–1.4)	1.70E-03	**
TCGA subtype	0.00	1 (0.88–1.1)	9.60E-01
HR score group	−0.56	0.57 (0.42–0.77)	2.60E-04	***
Immune checkpoint	−0.08	0.93 (0.87–0.99)	1.50E-02	*
CD 8 T effector	−0.10	0.91 (0.86–0.96)	3.30E-04	***
DDR	−0.04	0.96 (0.94–0.99)	4.80E-03	**
APM	−0.07	0.93 (0.87–1)	4.50E-02	*
CC Reg	0.10	1.1 (1–1.2)	1.80E-02	*
Fanconi	−0.07	0.94 (0.9–0.97)	7.80E-04	***
Gene19	0.03	1 (0.98–1.1)	2.40E-01
Tcga	0.01	1 (0.94–1.1)	8.30E-01
Histones	−0.08	0.92 (0.85–1)	5.00E-02
EMT1	0.02	1 (0.95–1.1)	6.30E-01
EMT2	0.03	1 (0.96–1.1)	4.00E-01
EMT3	0.01	1 (0.94–1.1)	7.40E-01
WNT target	0.17	1.2 (1–1.4)	8.30E-03	**
FGFR3 related	0.05	1.1 (0.95–1.2)	2.90E-01
Cell cycle	−0.03	0.97 (0.95–0.99)	1.30E-02	*
Mismatch repair	−0.06	0.95 (0.9–0.99)	2.70E-02	*
Homologous recombination	−0.08	0.93 (0.88–0.98)	3.40E-03	**
Nucleotide excision repair	−0.05	0.95 (0.91–1)	3.20E-02	*
DNA replication	−0.04	0.96 (0.92–0.99)	1.50E-02	*
Base excision repair	−0.05	0.95 (0.9–1)	4.20E-02	*
Risk score	0.82	2.3 (1.8–2.9)	5.70E-11	***

***p < 0.001; **p < 0.01; *p < 0.05.

TMB, tumor mutation burden; TNB, tumor neoantigen burden; IC, immune cells; TC, tumor cells; HR, homologous recombination; DDR, DNA, damage repair; APM: antigen processing and presentation machinery; CC, reg, cell cycle regulation.