TABLE 1.

The fold change for the notable lncRNAs that play roles in skin biology and/or diseases. Bold numbers denote FDR ≤0.05. Red results denote at least 1.5-fold change when comparing against control/unstimulated conditions. Expression in inflammatory skin disease represents findings in lesional skin of atopic dermatitis/psoriasis patients compared to control without skin disease.

lncRNA	Cell type detected	Expression in inflammatory skin disease		Expression in cytokine stimulated keratinocytes							Role
		AD	Pso	IFNa	IFNg	IL4	IL13	IL17A	IL17 + TNFa	TNFa
DANCR	KC	1.16	1.88	0.92	0.73	0.99	0.99	1.02	0.88	0.89	Helps maintain the non-differentiated state in the epidermal basal layer by associating with EZH2 (Hombach and Kretz, 2013; Tang et al., 2020)
TINCR	KC	0.67	0.65	1.00	0.68	1.09	1.07	0.97	0.77	0.94	Interacts with differentiation mRNAs and helps them bind to the STAU1 protein, increasing their stabilization (Hombach and Kretz, 2013; Tang et al., 2020)
H19	KC	0.31	0.05	0.85	0.71	0.82	0.94	0.92	0.71	0.89	Promotes keratinocyte differentiation by targeting MiR-130b-3p and inhibiting its activity on Dsg1 (Li et al., 2017; Tang et al., 2020)
NEAT1	Psoriatic Epidermis	1.14	1.44	0.97	0.74	0.96	0.91	1.02	0.97	0.93	Upregulated in AD and in proliferation of hemangioma tissues (Tang et al., 2020)
RNU1-1	KC	NA	1.63	1.01	1.00	1.00	1.01	1.00	1.01	1.00	Indicator for sun-induced skin injury. Change in U1 RNA structure by UVB induces cytokine expression (Hombach and Kretz, 2013)
UCA1	KC	1.76	2.97	0.60	0.68	0.71	0.76	0.77	0.72	0.71	Upregulates expression of A20 by inhibiting miR125a, which decreases activity of NF $\kappa$ B. It also downregulates IL-6, IL-8, IFN-y and inhibits melanogenesis (Tang et al., 2020; Ma et al., 2021)
SPRR2C	KC	8.51	245.06	1.01	1.23	0.87	0.96	1.88	6.92	1.14	Important in psoriasis pathogenesis and response to treatment. Upregulated in both psoriatic lesional skin and HaCaT cell lines in response to IL-22 treatment (Luo et al., 2021)
GAS5	Psoriatic Epidermis	NA	1.06	0.98	0.83	0.96	0.97	0.96	0.92	0.90	Indicator of psoriasis severity. Positive correlation between GAS5 and PASI (Ahmed Shehata et al., 2021)
MALAT1	Psoriatic Epidermis	1.08	1.02	1.02	0.76	0.94	1.07	1.03	1.12	0.98	Promote melanoma cell proliferation, invasion, and migration (Tang et al., 2020)