TABLE 1.
Median (range) urinary pH, volume, parent drug concentration, and cumulative excretion in volunteersa
| Drug and collection period (h) | Urinary pH | Vol (ml) | Conc (mg/liter) | Cumulative excretion (%) |
|---|---|---|---|---|
| Gemifloxacin | ||||
| 0–6 | 5.9 (5.2–8.3) | 293 (72–995) | 144 (59–282) | 16.5 (2.4–23.9) |
| 6–12 | 8.2 (5.9–8.5) | 529 (28–1,195) | 33 (11–70) | 22.5 (4.3–40.9) |
| 12–24 | 6.2 (5.2–7.0) | 713 (309–1,229) | 20 (6–40) | 27.3 (7.2–45.6) |
| 24–48 | 6.2 (5.7–8.2) | 1,368 (671–3,064) | 4 (1–13) | 29.1 (8.1–47.9) |
| 48–72 | 6.6 (5.2–8.0) | 1,534 (842–3,896) | 0.6 (0.1–2) | 29.4 (8.3–48.3) |
| 72–96 | 6.3 (5.6–7.8) | 1,240 (566–2,845) | 0.2 (0.1–0.6) | 29.5 (8.3–48.5) |
| 96–120 | 6.5 (5.3–8.1) | 1,304 (708–2,882) | 0.1 (0.06–0.4) | 29.6 (8.4–48.6) |
| 120–144 | 6.5 (5.4–7.8) | 1,442 (643–3,481) | 0.08 (0.02–0.1) | 29.7 (8.4–48.7) |
| Ofloxacin | ||||
| 0–6 | 5.8 (5.2–8.4) | 417 (157–784) | 427 (227–1107) | 41.8 (18.9–52.5) |
| 6–12 | 7.8 (5.8–8.9) | 623 (64–1450) | 145 (67–327) | 60.4 (31.1–75.9) |
| 12–24 | 6.1 (5.3–7.5) | 664 (316–1690) | 93 (25–197) | 75.5 (42.1–90.4) |
| 24–48 | 6.3 (5.6–8.0) | 1,495 (599–3,235) | 15 (2–30) | 82.9 (44.6–94.4) |
| 48–72 | 6.2 (5.3–7.8) | 1,353 (523–2,461) | 2 (0.8–4) | 83.9 (46.1–94.9) |
| 72–96 | 6.1 (5.4–7.8) | 1,263 (621–2,972) | 0.6 (0.2–1) | 84.1 (46.4–95.0) |
| 96–120 | 6.0 (5.3–7.6) | 1,465 (564–2,276) | 0.3 (LLQb–0.7) | 84.2 (46.5–95.1) |
| 120–144 | 6.6 (5.3–8.2) | 1,311 (691–2,210) | 0.2 (LLQ–0.3) | 84.3 (46.5–95.2) |
a
A total of 16 volunteers were tested.
b
LLQ, lower level of quantification.