TABLE 3.
Median (range) reciprocal UBTs for gemifloxacin and ofloxacin
| Drug and strain (no. of volunteers tested) | UBT for the following collection period (h):
|
AUBT | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 0–6 | 6–12 | 12–24 | 24–48 | 48–72 | 72–96 | 96–120 | 120–144 | ||
| Gemifloxacin | |||||||||
| E. coli ATCC 25922 (16) | ≥1,024 (128–≥1,024) | 384 (32–≥1,024) | 192 (4–≥1,024) | 48 (2–128) | 8 (0–32) | 2 (0–16) | 1 (0–4) | 0 (0–2) | 546 (174–816) |
| K. pneumoniae 595 (16) | 512 (16–≥1,024) | 128 (8–256) | 48 (1–256) | 12 (0–64) | 1.5 (0–8) | 0 (0–4) | 0 (0–1) | 0 | 321a (72–564) |
| P. mirabilis 414 (16) | 384 (32–≥1,204) | 64 (16–512) | 32 (1–512) | 6 (1–64) | 1 (0–4) | 0 (0–2) | 0 | 0 | 261a (120–510) |
| E. coli (Nx-res) 523 (16) | 128 (8–512) | 32 (4–128) | 16 (0–64) | 6 (0–16) | 0 (0–2) | 0 (0–1) | 0 | 0 | 237a (48–384) |
| P. aeruginosa 568 (16) | 8 (1–32) | 2 (0–8) | 1 (0–4) | 0 (0–1) | 0 | 0 | 0 | 0 | 48a (12–300) |
| S. aureus 83 (16) | ≥1,024 (128–≥1,024) | 256 (64–≥1,024) | 128 (8–512) | 32 (2–128) | 6 (1–32) | 2 (0–16) | 1 (0–4) | 0a (0–4) | 540a (246–834) |
| E. faecalis 60 (16) | 256 (32–512) | 64 (16–128) | 24 (2–128) | 6 (0–64) | 0.5 (0–4) | 0 (0–4) | 0 | 0 | 246a (96–516) |
| S. aureus 161 (13) | 32 (4–256) | 16 (2–128) | 4 (0–128) | 1 (0–16) | 0 (0–8) | 0 | 0 | 0 | 108 (0–408) |
| S. aureus 636 (16) | 8 (0–32) | 2 (0–8) | 1.5 (0–4) | 0 (0–2) | 0 (0–1) | 0 | 0 | 0 | 60a (0–144) |
| E. faecalis 55 (13) | 8 (1–32) | 2 (1–8) | 0 (0–2) | 0 (0–1) | 0 | 0 | 0 | 0 | 39a (0–102) |
| Ofloxacin | |||||||||
| E. coli ATCC 25922 (16) | ≥1,024 (256–≥1,024) | 512 (32–≥1,024) | 512 (8–≥1,024) | 64 (4–512) | 12 (0–64) | 2 (0–16) | 0 (0–4) | 0 (0–2) | 537 (258–888) |
| K. pneumoniae 595 (16) | ≥1,024 (64–≥1,024) | 256 (16–≥1,024) | 192 (16–≥1,024) | 32 (2–128) | 3 (0–16) | 0 (0–4) | 0 (0–1) | 0 (0–1) | 414a (180–636) |
| P. mirabilis 414 (16) | ≥1,024 (512–≥1,024) | 256 (64–≥1,024) | 192 (16–512) | 16 (2–128) | 4 (0–16) | 1 (0–8) | 0 (0–1) | 0 | 438a (276–654) |
| E. coli (Nx-res) 523 (16) | 256 (16–≥1,024) | 96 (8–512) | 48 (4–256) | 8 (0–64) | 0 (0–4) | 0 (0–1) | 0 | 0 | 276a (90–516) |
| P. aeruginosa 568 (16) | 32 (4–128) | 8 (2–32) | 3 (0–8) | 0.5 (0–4) | 0 (0–1) | 0 (0–1) | 0 (0–1) | 0 (0–1) | 99a (42–258) |
| S. aureus 83 (16) | 512 (128–≥1024) | 128 (4–512) | 64 (2–256) | 16 (2–64) | 2 (0–8) | 0 (0–2) | 0 (0–2) | 0 (0–1) | 387a (162–570) |
| E. faecalis 60 (16) | 32 (8–256) | 16 (8–64) | 8 (4–16) | 2 (0–4) | 0 (0–1) | 0 | 0 | 0 | 135a (90–204) |
| S. aureus 161 (13) | 16 (8–256) | 8 (0–64) | 4 (0–32) | 1 (0–2) | 0 | 0 | 0 | 0 | 105 (0–279) |
| S. aureus 636 (16) | 4 (0–32) | 2 (0–8) | 1 (0–2) | 0 (0–1) | 0 | 0 | 0 | 0 | 39a (0–78) |
| E. faecalis 55 (13) | 1 (0–8) | 0 (0–2) | 0 (0–2) | 0 | 0 | 0 | 0 | 0 | 0a (0–54) |
a
Significantly different (paired t test; P < 0.05) for gemifloxacin versus ofloxacin.