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. 2022 Apr 26;10:879877. doi: 10.3389/fcell.2022.879877

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Copyright © 2022 Liu, Qin, Liu, Mi, Zhang, Wang, Zhuang, Xu, Chen, Guo and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypo-exos significantly enhance the growth and migration of endothelial cells in vitro compared with Norm-exos. (A) Effects of Hypo-exos and Norm-exos on the viability of endothelial cells analyzed using the CCK-8 assay. (B) Effects of Hypo-exos and Norm-exos on the proliferation of endothelial cells assessed by immunofluorescence staining of Ki67; scale bars = 100 μm. (C) Percentage of Ki67-positive cells (%) quantified in (B). (D) Significantly increased closure of the scratched area in Hypo-exos treated group was observed in wound healing assays; scale bars = 200 μm. (E) Quantification of the rate of scratch closure (%) in (D). (F) Significantly higher number of endothelial cells in Hypo-exos group migrated to the bottom than Norm-exos group verified by Transwell migration assays; scale bars = 200 μm. (G) Quantification of the number of migrated HUVECs in (F). **p < 0.01, ***p < 0.001.