Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 26;10:879877. doi: 10.3389/fcell.2022.879877

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Liu, Qin, Liu, Mi, Zhang, Wang, Zhuang, Xu, Chen, Guo and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Hypo-exos promote micro-vessel formation in vivo compared with Norm-exos. (A) Representative images of Matrigel plugs implanted subcutaneously in mice for 10 days. (B) Quantification of the number of micro-vessels around the plug implants. (C) Immunofluorescence staining for VEGF in implanted matrigel plugs containing Hypo-exos or Norm-exos. Scale bars = 500 μm. (D) Quantification of VEGF expression in Matrigel plugs. (E) Increased neovasculature in matrigel plugs containing Hypo-exos visualized by immunofluorescence staining of CD31; scale bars = 500 μm. (F) Quantification of the number of tubular structures stained by CD31. *p < 0.05.