Table 3. Results of included studies.
| Study | Patient-centered outcome | Vitamin E baseline mean score | Control baseline mean score | Vitamin E mean score post-therapy | Control score post-therapy | Intergroup post-therapy mean difference (95% CI) | Key results |
|---|---|---|---|---|---|---|---|
| Ziagham et al. [27] (2012) | CSVS | 2.41 ± 4.65 | 4.7 ± 2.81 | 0.65 ± 0.875 | 0.15 ± 0.489 | –0.50 (–0.95 to –0.05) P = 0.032 |
Hyaluronic acid superior to low dose vitamin E |
| Ziagham et al. [23] (2013) | CSVS | 4.65 ± 2.41 | 6.95 ± 1.58 | 0.65 ± 0.875 | 5.95 ± 1.73 | 5.3 (4.4 to 6.2) P < 0.001 |
Low dose vitamin E superior to placebo |
| Golmakani et al. [28] (2019) | ASFQ | 23.88 ± 8.86 | 26.88 ± 7.95 | 34.23 ± 7.52 | 34.42 ± 7.44 | –0.19 (–4.4 to 4.0) P = 0.927 |
No significant difference between estrogen & high dose vitamin E |
| Parnan Emamverdikhan et al. [29] (2014) | MEQOL | 70.03 ± 26.34 | 64 ± 27.83 | 33 ± 18.26 | 29.53 ± 18.65 | –3.47 (–13.8 to 6.8) P = 0.50 |
No significant difference between estrogen & high dose vitamin E |
CSVS: Composite Score of Vaginal Symptoms, ASFQ: Abbreviated Sexual Function Questionnaire, MEQOL: Menopause-Specific Quality of Life, CI: confidence interval.