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. 2022 May 10;23:35. doi: 10.1186/s12863-022-01054-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — WGCNA. A Scale independence and mean connectivity of various soft-thresholding values (β). The left panel (A) displayed the influence of soft-thresholding power (X-axis) on the scale-free fit index (Y-axis). The right panel (A) showed the influence of soft-thresholding power (X-axis) on the mean connectivity (degree, Y-axis). B Cluster dendrogram of all filtered genes enriched based on the dissimilarity measure and the cluster module colors. C Matrix with Module-Trait Relationships (MTRs) and corresponding P-values between the detected modules on the y-axis and sexes (female and male) on the x-axis. D Heatmap of the adjacencies of modules. Red represented positive correlation and blue represented negative correlation. The male group clustered with the greenyellow module, and the female group clustered with the green module. Association between the module membership and gene significance within the greenyellow module (E) and the green module (F). WGCNA, weighted gene co-expression network analysis