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. 2022 May 10;23:35. doi: 10.1186/s12863-022-01054-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Protein protein interaction (PPI) network for the greenyellow module. A The whole PPI network. There were 122 nodes and 238 edges in the network. These nodes (circles) represented genes, and bigger nodes represented genes with more links. Edges (gray lines) between nodes indicated the interaction of genes in the network. Yellow circles represented non DEGs. Red circles represented up-regulated DEGs. Blue circles represented down-regulated DEGs. DEGs (females compared with males). B The PPI sub-network. There were 10 nodes and 34 edges in the network. Color represented Maximal Clique Centrality (MCC) score, and the darker the color, the higher MCC score of the node. Diamond nodes represented down-regulated DEGs. DEGs (females compared with males). Functional enrichment analysis for eight hub genes, including KEGG enrichment analysis (C) and GO enrichment analysis (D). Top 10 terms and top 5 terms ordered by P.adjust for the KEGG and GO enrichment analysis, respectively. P.adjust indicated the degree of enrichment, with smaller P.adjust indicating terms that were more likely to play significantly functional roles