Molecules that mediate resistance to cancer therapy agents, as identified by use of the CRISPR-Cas9 system.

Therapeutic agents		Molecules involved in resistance	Cancer	Result
Molecular targeted agents	Trastuzumab	HER2	Breast cancer	Reverses drug resistance34
	Bortezomib	Rpn13	Multiple myeloma	Reduces the survival of MM cells and inhibits proliferation36
	SAHA	p57	Pancreatic ductal adenocarcinoma	Reverses drug resistance39
	Imatinib	ASXL1	Chronic myelocytic leukemia	Slows down cell growth and enhances in differentiation ability40
	Ispinesib	Kinesin-5 A133P	Cervical cancer	Overthrows the previous resistance mechanism42
Cytotoxic agents	Cisplatin	p53,CTR	Oesophageal adenocarcinoma	Induces cell cycle arrest and inhibits cancer cells growth44
	Epirubicin	MLL	Bladder cancer	Reverses drug resistance47
	Paclitaxel	Rsf-1	Lung cancer	Reverses drug resistance51
	Doxorubicin	P-glycoprotein	Breast cancer	Increases sensitivity to doxorubicin28
Immunotherapy	Cancer vaccines and adoptive T cell therapies	PBAF	Melanoma	Increases sensitivity to immunotherapy54