Table 2. Cox regression for training cohort.
| Variables | Univariate analysis | Multivariable analysis | |||
| HR (95% CI) | P | HR (95% CI) | P | ||
| KPS, Karnofsky performance status; LN, lymph node; NLR, neutrophil to lymphocyte ratio; MPV, mean platelet volume; cTNM, clinical TNM stage; pTNM, pathological TNM stage; HR, hazard ratio; 95% CI, 95% confidence interval. | |||||
| Age (year) | |||||
| <65 | 1 (reference) | ||||
| ≥65 | 1.11 (0.89−1.40) | 0.352 | |||
| Gender | |||||
| Male | 1 (reference) | 1 (reference) | |||
| Female | 0.54 (0.39−0.75) | <0.001 | 0.61 (0.44−0.84) | 0.003 | |
| KPS | |||||
| 90−100 | 1 (reference) | ||||
| 70−80 | 1.00 (0.81−1.23) | 0.992 | |||
| Tumor location | |||||
| Upper | 1 (reference) | ||||
| Middle | 0.95 (0.75−1.20) | 0.682 | |||
| Lower | 0.92 (0.69−1.23) | 0.576 | |||
| Differentiation | |||||
| G1 | 1 (reference) | ||||
| G2 | 1.14 (0.85−1.53) | 0.380 | |||
| G3 | 1.24 (0.93−1.65) | 0.141 | |||
| Surgical margin | |||||
| R0 | 1 (reference) | ||||
| R1/2 | 1.56 (1.06−2.30) | 0.023 | |||
| Vascular invasion | |||||
| No | 1 (reference) | ||||
| Yes | 1.68 (1.32−2.14) | <0.001 | |||
| Neural invasion | |||||
| No | 1 (reference) | ||||
| Yes | 1.56 (1.21−2.01) | <0.001 | |||
| Resected LN number | |||||
| <20 | 1 (reference) | ||||
| ≥20 | 1.03 (0.84−1.27) | 0.749 | |||
| Na (mmol/L) | |||||
| <139 | 1 (reference) | 1 (reference) | |||
| ≥139 | 0.78 (0.61−0.98) | 0.036 | 0.79 (0.62−0.99) | 0.045 | |
| NLR | |||||
| <3.5 | 1 (reference) | ||||
| ≥3.5 | 1.01 (0.80−1.28) | 0.904 | |||
| MPV (fL) | |||||
| <12.7 | 1 (reference) | ||||
| ≥12.7 | 0.81 (0.64−1.03) | 0.084 | |||
| cTNM | |||||
| I | 1 (reference) | ||||
| II | 3.58 (0.88−14.51) | 0.074 | |||
| III | 3.46 (0.86−13.98) | 0.082 | |||
| IV | 4.72 (1.17−19.07) | 0.029 | |||
| pTNM (8th) | |||||
| I | 1 (reference) | 1 (reference) | |||
| II | 1.98 (1.02−3.81) | 0.042 | 1.48 (0.76−2.87) | 0.245 | |
| III | 4.91 (2.60−9.27) | <0.001 | 3.36 (1.76−6.41) | <0.001 | |
| IV | 8.86 (4.58−17.14) | <0.001 | 4.86 (2.44−9.66) | <0.001 | |
| Radiomics index (continuous) | 3.54 (2.72−4.61) | <0.001 | 2.12 (1.59−2.83) | <0.001 | |