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. 2022 Apr 30;34(2):95–108. doi: 10.21147/j.issn.1000-9604.2022.02.04

Table S4. Detection of CTCs through optimized detection model and CTCs characterized by single marker gene (EpCAM, MUC1 and WT1) in EOC patients with different levels of chemo-sensitivity .

Marker N n (%) χ 2 P
Sensitivity Resistance
CTC, circulating tumor cell; EOC, epithelial ovarian cancer. CTCEpCAM positive defined as EpCAM PCR concentration ≥0.195 ng/μL; CTCMUC1 positive defined as MUC1 PCR concentration ≥0.355 ng/μL; CTCWT1 positive defined as WT1 PCR concentration ≥0.305 ng/μL.
CTCs
 Positive 121 93 (76.9) 28 (23.1) 1.913 0.167
 Negative 33 29 (87.9) 4 (12.1)
CTCEpCAM
 Positive 95 70 (73.7) 25 (26.3) 4.617 0.032
 Negative 59 52 (88.1) 7 (11.9)
CTCMUC1
 Positive 87 64 (73.6) 23 (26.4) 3.888 0.049
 Negative 67 58 (86.6) 9 (13.4)
CTCWT1
 Positive 91 72 (79.1) 19 (20.9) 0.001 0.971
 Negative 63 50 (79.4) 13 (20.6)