Table S4. Detection of CTCs through optimized detection model and CTCs characterized by single marker gene (EpCAM, MUC1 and WT1) in EOC patients with different levels of chemo-sensitivity .
Marker | N | n (%) | χ 2 | P | |
Sensitivity | Resistance | ||||
CTC, circulating tumor cell; EOC, epithelial ovarian cancer. CTCEpCAM positive defined as EpCAM PCR concentration ≥0.195 ng/μL; CTCMUC1 positive defined as MUC1 PCR concentration ≥0.355 ng/μL; CTCWT1 positive defined as WT1 PCR concentration ≥0.305 ng/μL. | |||||
CTCs | |||||
Positive | 121 | 93 (76.9) | 28 (23.1) | 1.913 | 0.167 |
Negative | 33 | 29 (87.9) | 4 (12.1) | ||
CTCEpCAM | |||||
Positive | 95 | 70 (73.7) | 25 (26.3) | 4.617 | 0.032 |
Negative | 59 | 52 (88.1) | 7 (11.9) | ||
CTCMUC1 | |||||
Positive | 87 | 64 (73.6) | 23 (26.4) | 3.888 | 0.049 |
Negative | 67 | 58 (86.6) | 9 (13.4) | ||
CTCWT1 | |||||
Positive | 91 | 72 (79.1) | 19 (20.9) | 0.001 | 0.971 |
Negative | 63 | 50 (79.4) | 13 (20.6) |